Harmful Effects Research Articles

Mellisa officinalis Leaf Extract Green-Synthesized AgNPs: Investigation of Its Anaesthetic and Analgesic Activities

Investigating and studying natural origin agents, such as nanocompounds obtained from plants that have less harmful effects, is the main research aim in the field of treatment of diseases. For this goal, extensive research have been performed on several medicinal herbs and their nanoparticles, and their cytotoxic and therapeutic properties have been determined. In the current experiment, the Ag nanoparticles green-synthesis were carried out by the Mellisa officinalis extract. The formulated NPs were analyzed by FESEM, TEM, and UV-Vis. In the in vivo design, after oral administration, paw edema was significantly decreased in mice. CH3COOH-induced writhing episodes were dose-dependently and significantly decreased. The results of anesthetic activity were indicated that the nanoparticles made the local anesthetic effects in guinea pig and frog models. In addition, the analgesic and anti-inflammatory properties were determined in several doses.

Power Generation Using Gravity

Abstract: In recent times due to effect of pollution and global warming there is a need for generating power from renewable sources. The reason for generating power using gravity is that it is available all over the Earth, abundant and consistent too. This method utilizes the force of gravity to drive mechanical systems, such as falling weights or water, which in turn generate electricity. Due to the development and modernization the electricity demand is increasing at high extent. To fulfil this demand globally which is without any harmful effect on environment is possible by using gravity power generation. In recent times due to effects of pollution there is a need for generating power from renewable sources. In this project, the gravitational energy of a heavy particle is converted to the electrical energy. When the heavy particle falls down from a higher altitude to a lower one, its potential energy is converted into the kinetic energy. Then this energy is converted to electricity by using a synchronous motor. When increasing the altitude of the load, the lighting time increases. If load increases, power production also increases

Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice

Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed the hepatitis B virus and hepatitis C virus as the leading cause of chronic liver disease in most parts of the Western world. MASLD (formerly known as NAFLD) encompasses both simple steatosis and more aggressive metabolic dysfunction-associated steatohepatitis (MASH), which is accompanied by inflammation, fibrosis, and cirrhosis, and ultimately can lead to hepatocellular carcinoma (HCC). There are currently very few approved therapies for MASH. Weight loss strategies such as caloric restriction can ameliorate the harmful metabolic effect of MASH and inhibit HCC; however, it is difficult to implement and maintain in daily life, especially in individuals diagnosed with HCC. In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC.

Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis.

Low dissolved oxygen (LO) conditions represent a major environmental challenge to marine life, especially benthic animals. For these organisms, drastic declines in oxygen availability (hypoxic events) can trigger mass mortality events and thus, act as agents of selection influencing the evolution of adaptations. In sea cucumbers, one of the most successful groups of benthic invertebrates, the exposure to hypoxic conditions triggers adaptive adjustments in metabolic rates and behaviour. It is unclear, however, how these adaptive responses are regulated and the genetic mechanisms underpinning them. Here, we addressed this knowledge gap by assessing the genetic regulation (transcription and translation) of hypoxia exposure in the sea cucumber Apostichopus japonicus. Transcriptional and translational gene expression profiles under short- and long-term exposure to low oxygen conditions are tightly associated with extracellular matrix (ECM)-receptor interaction in which laminin and collagen likely have important functions. Finding revealed that genes with a high translational efficiency (TE) had a relatively short upstream open reading frame (uORF) and a high uORF normalized minimal free energy, suggesting that sea cucumbers may respond to hypoxic stress via altered TE. These results provide valuable insights into the regulatory mechanisms that confer adaptive capacity to holothurians to survive oxygen deficiency conditions and may also be used to inform the development of strategies for mitigating the harmful effects of hypoxia on other marine invertebrates facing similar challenges.

Detection of Deepfake Media Using a Hybrid CNN–RNN Model and Particle Swarm Optimization (PSO) Algorithm

Deepfakes are digital audio, video, or images manipulated using machine learning algorithms. These manipulated media files can convincingly depict individuals doing or saying things they never actually did. Deepfakes pose significant risks to our lives, including national security, financial markets, and personal privacy. The ability to create convincing deep fakes can also harm individuals’ reputations and can be used to spread disinformation and fake news. As such, there is a growing need for reliable and accurate methods to detect deep fakes and prevent their harmful effects. In this paper, a hybrid convolutional neural network (CNN) and recurrent neural network (RNN) with a particle swarm optimization (PSO) algorithm is utilized to demonstrate a deep learning strategy for detecting deepfake videos. High accuracy, sensitivity, specificity, and F1 score were attained by the proposed approach when tested on two publicly available datasets: Celeb-DF and the Deepfake Detection Challenge Dataset (DFDC). Specifically, the proposed method achieved an average accuracy of 97.26% on Celeb-DF and an average accuracy of 94.2% on DFDC. The results were compared to other state-of-the-art methods and showed that the proposed method outperformed many. The proposed method can effectively detect deepfake videos, which is essential for identifying and preventing the spread of manipulated content online.

Occurrence and Risk Assessment of Antibiotics in Urban River–Wetland–Lake Systems in Southwest China

Antibiotics in the aquatic environment are of great concern as novel contaminants. In this study, we investigated the occurrence, distribution, potential sources, and risk assessment of antibiotics in an interconnected river–wetland–lake system. Thirty-three target antibiotics, including sulfonamides (SAs), macrolides (MLs), fluoroquinolones (FQs), tetracyclines (TCs), and chloramphenicol (CLs) belong to five common groups of antibiotics, were tested from water samples collected in the Panlong River, Xinghai Wetland, and Lake Dian (or Dianchi). Mass spectrophotometry was used to detect the target antibiotics, and the water quality parameters were measured in situ. We found four antibiotics, lincomycin (LIN), trimethoprim (TMP), sulfamethoxazole (SMX), and ofloxacin (OFL), with relatively low concentrations at the ng/L level, and detection rates among sample sites ranged from 42.3% to 76.9%, with maximum concentrations of 0.71 ng/L~5.53 ng/L. TMP was not detected in the Panlong River but appeared in the wetlands and Lake Dian. Midstream urban areas of the Panlong River showed the highest pollution among sites. Antibiotic concentrations were positively correlated with total nitrogen (TN) (p < 0.05) and showed some negative correlation with pH, salinity, and DO. According to the risk assessment, antibiotics in water do not pose a threat to human health and aquatic ecosystems, but a potentially harmful combined effect cannot be excluded. Our research offers a geographical summary of the distribution of antibiotics in urban river, wetland, and lake ecosystems in the plateau (PWL), which is important for predicting the distribution characteristics of antibiotics in the plateau water environment and establishing a standardized antibiotic monitoring and management system for the government.

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms.

The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

Air Pollution as a Problem of the Modern World

Research relevance: the development of diseases and pathological conditions caused by air pollution depends on the types of pollutants, their physical and chemical characteristics, while air pollution increases the incidence of respiratory diseases. Research objectives: to develop a scheme for the pathogenesis of the development of immunological disorders in the body of people living in conditions of exposure to atmospheric air pollutants, to conduct a statistical analysis of factors influencing the development of allergic rhinitis and the development of bronchial asthma. Research materials and methods: a study of the characteristics of atmospheric air was carried out in three places in Kyrgyzstan: in the area of ​​the village Papan, near the village Gulbar, and Aravan district and near the Osh city. The study was an open, prospective, non-interventional, observational study in parallel groups. The study participants included residents of three regions of the Kyrgyz Republic, depending on the degree of air pollution. Research results: the data obtained indicated that people living in different regions of the Kyrgyz Republic with varying degrees of atmospheric pollution exhibit significant differences in indicators indicating pathology of the upper respiratory tract and allergization of the body. Conclusions: The harmful effects of air pollution and climate change on human health can be largely prevented through the timely adoption of the necessary legislation.

Beyond bias: Aggregate approaches to conflicts of interest research and policy in biomedical research

AbstractConsiderable efforts have been devoted to addressing the problem of conflicts of interest (COI) in health research, policy, education, and practice. An overwhelming body of evidence demonstrates that conflicts associate with deleterious outcomes for the biomedical research enterprise. Nevertheless, little has changed for research, specifically, since the Institute of Medicine's landmark Conflicts of Interest in Medical Research, Practice, and Education was published over a decade ago. In this article, we draw on interdisciplinary research on manufactured controversies in science‐policy deliberation to argue that the development of meaningful COI policy has been stymied through argumentative “wedges” designed to delay consensus and policy formation. Argumentative wedges disrupt policy formation by mischaracterizing the evidence base, continuously redefining the terms of the debate and/or recommending overly narrow criteria for who should be allowed to participate in policy deliberation. In this article, we argue researchers and policymakers interested in better addressing the harmful effects of COI can improve their efforts through strategic efforts designed to disrupt the wedges of manufactured controversy. Additionally, we argue that efforts to address COI can be further enhanced through embracing a broader framework for COI inquiry. Specifically, we argue that aggregate approaches to COI can help to disrupt these wedges and provide a strong foundation for future policy.

Impact of pesticide use on farmers health condition: case control design

With global populations growing, it is becoming increasingly impossible to ignore food and energy demands. Livestock and agricultural activities produce a large quantity of food. Though the use of agrochemicals has increased agricultural output, they have also been linked to a number of harmful clear adverse effects on human. chemical Pesticides poisonous compounds that negative effect on consumers. the study conducted a case-control was carried out to investigate variations among intact groups on an independent variable of interest. A random sampling approach was employed for 201 farmers. 098Farmers in the research group were exposed to pesticides, whereas farmers in the control group did not apply pesticides. The data were gathered using a survey (PHQ-15)-based on interviews conducted by the investigator. The current study was carried out in five districts (Al-Mashkhab, Al-Abbasiya, Al-hrea, Al-hera, and Al-qadisya). According to the study findings, total farmers' reactions to general physical condition among study group participants are substantially influenced, however, participant of control group show not effected. The negative health effect for farmers spray and exposed to pesticides shows nausea or vomiting, blurred vision, headache, bronchial sensitivity, skin irritation, and shortness of breath eye irritation. the current survey show the Insecticides are the most often used chemicals. The research indicated that pesticide use and exposure have an influence on human health and have a wide range of adverse health effects. According to the findings of the current study, it is critical to use personal protection equipment (PPE) while spraying. Also, undertake a comprehensive exam on farmers on a regular basis.

Effect of bioremediation or organic treatments of soil contaminated with some heavy metals on the biological and L- glutaminase activity

For the purpose of identify the ability of bioremediation or organic treatments of soil to reduce the harmful effect of heavy metals including Zn, pb and cd on the biological activity such as soil respiration, the total number of fungi and the activity of the L-glutaminase enzyme have been studied. A laboratory incubation experiment was applied in the Soil Microbiology Laboratory in the Department of Soil Sciences and Water Resources in the College of Agriculture– Basrah University. The soil of the surface layer (0-30 cm) from Qurna district, north of Basrah province was contaminated with the critical levels of the heavy metals cd, Pb, Zn and were placed in an incubator at 30°C for 14 days. The biological and organic treatments process was applied by inoculating soil contaminated with Aspergillus niger or humic acid (40 L ha-1) or sterilized cow manure (4%), incubated at 25°C for 30 days, then some biological parameters were estimated at the periods of 10, 20 and 30 days. Results have been showed that an inhibitory effect of the studied heavy metals on the biological parameters, and the Cd has been recorded the highest percentage of inhibition of total number of fungi (30.67%), the amount of CO2 released (13.93%) and the activity of the L-glutaminase enzyme (45.33%) compared to the control treatment. The ability of the treatments materials to remove heavy metals were (89.02%) for A. niger compared to humic acid (63.48%) and cow manure (48.71%). It was reflected in an increase in the number of fungi, which recorded 152, 167.75, 174.5 cfu g-1 when treated with A. niger, cow manure and humic acid, respectively compared to the control treatment which was (65.92 cfu g-1). The biological and organic treatments also increased the level of liberated CO2 from the polluted soil to 268.62, 253.86, 303.59 mg CO2 g-1, respectively compared to the control treatment. The activity of the L-glutaminase enzyme has increased due to application of treatments. It was 57.02, 48.97, 70.41 µg NH4+ g-1 2hr.-1 for inoculated with A. niger or treated with cow manure and humic acid, respectively, while the control treatment was 37.19 µg NH4+ g-12hr.-1.

New trends on personalized sunscreens.

Nowadays, there are emerging trends in customized and personalized photoprotection, focusing on the innovative approaches to enhance sun protection efficacy tailored to individual needs. We conducted an electronic search of the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Skin Group Specialised Skin Register, and TESEO. Specific search terms related to personalized photoprotection and the variables of age, genetic predisposition, skin phototype, photodermatosis, and physiological conditions such as pregnancy, as well as lifestyle habits were used. The article highlights the challenges and opportunities in adopting personalized photoprotection strategies, aiming to promote skin health and prevent the harmful effects of UV radiation in the era of precision medicine.

Prevalence and determinants of areca nut use among pregnant women in India

ABSTRACT Background Areca nut is the fourth most commonly used substance worldwide after nicotine, alcohol, and caffeine. Women in many countries use it in cultural and religious ceremonies. The use of areca nut is harmful to health; but when women consume it during pregnancy, it exerts several harmful effects on the fetus. This paper examines the prevalence and determinants of areca nut use among pregnant women in India. Methods Data from the Global Adult Tobacco Survey-2, India, are used for analysis (N = 1403 pregnant women). Multiple classification analysis and multivariate logistic regression model were applied to estimate the effect of various determinates. Results About 16% pregnant women used areca nut in any form in India. Areca nut use with (24%) and without (13%) tobacco was higher among scheduled tribes. Region, caste, religion, place of residence, educational attainment, occupation, and economic status are found to be important determinants of areca nut use. Conclusion More specific programs which can effectively reduce the use of areca nut among pregnant women should be adopted. Programs related to prevention of areca nut use should be expanded effectively through health awareness interventions during pregnancy, including media messages, and involvement of frontline health workers, especially focusing on the socio-economically backward groups.

A model of alcoholic liver disease based on different hepatotoxics leading to liver cancer

The worst-case scenario related to alcoholic liver disease (ALD) arises after a long period of exposure to the harmful effect of alcohol consumption along with other hepatotoxics. ALD encompasses a broad spectrum of liver-associated disorders, such as steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Based on the chronic administration of different hepatotoxics, including ethanol, sucrose, lipopolysaccharide, and low doses of diethylnitrosamine over a short period, here we aimed to develop a multiple hepatotoxic (MHT)-ALD model in the mouse that recapitulates the human ALD-associated disorders. We demonstrated that the MHT-ALD model induces ADH1A and NXN, an ethanol metabolizer and a redox-sensor enzyme, respectively; promotes steatosis associated with the induction of the lipid droplet forming FSP27, inflammation identified by the infiltration of hepatic neutrophils-positive to LY-6G marker, and the increase of MYD88 level, a protein involved in inflammatory response; and stimulates the early appearance of cellular senescence identified by the senescence markers SA-β-gal activity and p-H2A.XSer139. It also induces fibrosis associated with increased desmin, a marker of hepatic stellate cells whose activation leads to the deposition of collagen fibers, accompanied by cell death and compensatory proliferation revealed by increased CASP3-mediated apoptosis, and KI67- and PCNA-proliferation markers, respectively. It also induces histopathological traits of malignancy and the level of the HCC marker, GSTP1. In conclusion, we provide a useful model for exploring the chronological ALD-associated alterations and stages, and addressing therapeutic approaches.

Detrimental Effects of Slate Pencil : A Review

Slate pencil dust, often used in various cultures for its sensory properties, presents a concerning health hazard when inhaled or ingested. The possible harmful effects of slate pencil dust on human health are summed up in this article. The dust’s tiny particles, which are mostly made of minerals like kaolinite and talc, can cause gastrointestinal disorders, respiratory ailments, and dangers to one’s general health. The sources of exposure, the physiological effect of slate pencil dust, and the significance of increasing public awareness are all covered in this review. The result emphasize how important it is to promote safe alternatives and implement preventive measures in order to reduce the health risk related to exposure to slate pencil dust.

Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk

BackgroundThe global use of plastic materials has undergone rapid expansion, resulting in the substantial generation of degraded and synthetic microplastics and nanoplastics (MNPs), which have the potential to impose significant environmental burdens and cause harmful effects on living organisms. Despite this, the detrimental impacts of MNPs exposure towards host cells and tissues have not been thoroughly characterized.ResultsIn the present study, we have elucidated a previously unidentified hepatotoxic effect of 20 nm synthetic polystyrene nanoparticles (PSNPs), rather than larger PS beads, by selectively inducing necroptosis in macrophages. Mechanistically, 20 nm PSNPs were rapidly internalized by macrophages and accumulated in the mitochondria, where they disrupted mitochondrial integrity, leading to heightened production of mitochondrial reactive oxygen species (mtROS). This elevated mtROS generation essentially triggered necroptosis in macrophages, resulting in enhanced crosstalk with hepatocytes, ultimately leading to hepatocyte damage. Additionally, it was demonstrated that PSNPs induced necroptosis and promoted acute liver injury in mice. This harmful effect was significantly mitigated by the administration of a necroptosis inhibitor or systemic depletion of macrophages prior to PSNPs injection.ConclusionCollectively, our study suggests a profound toxicity of environmental PSNP exposure by triggering macrophage necroptosis, which in turn induces hepatotoxicity via intercellular crosstalk between macrophages and hepatocytes in the hepatic microenvironment.

Medium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review

Pathomechanisms of dementias involve increasing damage to neuronal energy metabolism, resulting in degeneration-related insulin resistance and glucose hypometabolism. In this case, ketone bodies can provide an alternative energy source. Supplementation with medium-chain triglycerides (MCTs), which can induce ketogenesis, may alleviate brain energy deficits and improve neuronal function. This review aims to determine the effectiveness of MCT as a symptomatic treatment approach. The systematic literature search was conducted in April 2023 following the Cochrane Handbook and PRISMA guidelines. A total of 21 studies were included, comprising eight uncontrolled trials and 13 RCTs investigating the effects of MCT on Alzheimer’s disease (AD) and mild cognitive impairment (MCI). A substantial increase in plasma ketone levels and brain metabolic rates was observed. Cognitive assessments showed only occasional or domain-specific performance improvements. The effects on functional abilities or psychological outcomes have been inadequately studied. Besides gastrointestinal side effects, no harmful effects were observed. However, the evidence was severely weakened by heterogeneous and poorly designed study protocols, bias, and conflicts of interest. In conclusion, the ketogenic properties of MCTs may have beneficial effects on brain metabolism in AD and MCI but do not always result in measurable clinical improvement. Current evidence is insufficient to recommend MCT as a comparable symptomatic treatment option.

Mulberry branch fiber improved lipid metabolism and egg yolk fatty acid composition of laying hens via the enterohepatic axis

BackgroundThe utilization of mulberry branch fiber (MF), the largest by-product of the sericulture industry, is an important issue. Supplementation with MF as a dietary fiber for poultry may serve as a useful application. However, little is known about the effects of MF on liver lipid metabolism and egg yolk fatty acid composition of laying hens and their underlying mechanisms. In this study, we performed a multi-omics investigation to explore the variations in liver lipid metabolism, egg yolk fatty acid composition, gut microbiota, and the associations among them induced by dietary MF in laying hens.ResultsDietary MF had no harmful effects on the laying performance or egg quality in laying hens. The enzyme activities associated with lipid metabolism in the liver were altered by the addition of 5% MF, resulting in reduced liver fat accumulation. Furthermore, dietary 5% MF induced the variation in the fatty acid profiles of egg yolk, and increased the polyunsaturated fatty acid (PUFA) content. We observed a significant reduction in the diversity of both gut bacteria and changes in their compositions after the addition of MF. Dietary MF significantly increased the abundance of genes involved in fatty acid biodegradation, and short-chain fatty acids biosynthesis in the gut microbiota of laying hens. The significant correlations were observed between the liver lipid metabolism enzyme activities of hepatic lipase, lipoprotein lipase, and total esterase with gut microbiota, including negative correlations with gut microbiota diversity, and multiple correlations with gut bacteria and viruses. Moreover, various correlations between the contents of PUFAs and monounsaturated fatty acids in egg yolk with the gut microbiota were obtained. Based on partial-least-squares path modeling integrated with the multi-omics datasets, we deduced the direct effects of liver enzyme activities and gut bacterial compositions on liver fat content and the roles of liver enzyme activities and gut bacterial diversity on egg yolk fatty acid composition.ConclusionsThe results indicate that dietary MF is beneficial to laying hens as it reduces the liver fat and improves egg yolk fatty acid composition through the enterohepatic axis.CByDGCz_6LcoMs-GQqtpHGVideo Graphical

NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention

NOD-like receptor protein 3 (NLRP3) inflammasome is an intracellular sensing protein complex that possesses NACHT, leucine-rich repeat, and pyrin domain, playing a crucial role in innate immunity. Activation of the NLRP3 inflammasome leads to the production of pro-inflammatory cellular contents, such as interleukin (IL)-1β and IL-18, and induction of inflammatory cell death known as pyroptosis, thereby amplifying or sustaining inflammation. While a balanced inflammatory response is beneficial for resolving damage and promoting tissue healing, excessive activation of the NLRP3 inflammasome and pyroptosis can have harmful effects. The involvement of the NLRP3 inflammasome has been observed in various cardiovascular diseases (CVD). Indeed, the NLRP3 inflammasome and its associated pyroptosis are closely linked to key cardiovascular risk factors including hyperlipidemia, diabetes, hypertension, obesity, and hyperhomocysteinemia. Exercise compared with medicine is a highly effective measure for both preventing and treating CVD. Interestingly, emerging evidence suggests that exercise improves CVD and inhibits the activity of NLRP3 inflammasome and pyroptosis. In this review, the activation mechanisms of the NLRP3 inflammasome and its pathogenic role in CVD are critically discussed. Importantly, the purpose is to emphasize the crucial role of exercise in managing CVD by suppressing NLRP3 inflammasome activity and proposes it as the foundation for developing novel treatment strategies.

The Use of Sargassum spp. Ashes Like a Raw Material for Mortar Production: Composite Performance and Environmental Outlook

The accumulation of brown algae from the genus Sargassum has been increasing over the years in coastal regions of the Caribbean, Africa, Brazil, and Mexico. This causes harmful effects to the ecosystem, human health, the economy, and the climate due to gas emissions from its decomposition process. There is the possibility of this biomass being reused in civil construction, and some studies have been carried out on its application to common Portland cement mortar. As such, the objective of this study is to evaluate the potential of sargassum ash as a mineral addition to partially replace fine aggregates in Portland cement mortar. Characterization of the raw materials was carried out through X-ray fluorescence spectroscopy, loss on ignition, particle size distribution, Brunauer–Emmett–Teller (BET) analysis, real density, X-ray diffraction, scanning electron microscopy, and dispersion spectroscopy of electrons. The mortars were prepared by partially replacing the fine aggregate (sand) with sargassum ash at 0%, 5%, 10%, and 20%. Mortar performance was evaluated through water absorption, apparent porosity, apparent specific mass, and compressive strength 7, 28, and 63 days after curing. Lastly, a life cycle assessment was conducted in accordance with ISO standards 14040:2006 and 14044:2006. The results showed that replacing sand with sargassum ash increases water absorption and apparent porosity, and decreases the apparent specific mass and compressive strength as replacement increases. Nevertheless, the compressive strength results after 63 days for 5 and 10% replacement did not differ statistically from reference values. The life cycle assessment indicated that mortars with partial replacement of sand by sargassum ash show positive environmental impacts when compared to reference values for most categories, regardless of the scenario analyzed, especially for mortar with 10% replacement. As such, the use of sargassum ash at 10% does not alter the mortar’s compressive strength values after 63 days, but does reduce its environmental impact. The application of this biomass in civil construction materials provides a destination for this algae, and that can be a solution to mitigate the social, environmental, and economic problems it has been causing.